Archaeal transcription and its regulators

Factor-dependent archaeal transcription termination.

RNA polymerase activity is regulated by nascent RNA sequences, DNA template sequences, and conserved transcription factors. Transcription factors promoting initiation and elongation have been characterized in each domain, but transcription termination factors have been identified only in bacteria and eukarya. Here we describe euryarchaeal termination activity (Eta), the first archaeal terminati...

Archaeal Histones, Nucleosomes, and Transcription Initiation

Methanobacterium thermoautotrophicum and Metha-nobacterium formicicum, and five in Methanococcus and Charles J. Daniels Department of Microbiology jannaschii, two of which are plasmid-encoded (Bult et al., 1996; Grayling et al., 1996). In most cases, the primary sequences of the archaeal histones within one species are more similar to each other than to the sequences of histones in other Archae...

Archaeal transcription: making up for lost time.

In recent years, emerging structural information on the aRNAP (archaeal RNA polymerase) apparatus has shown its strong evolutionary relationship with the eukaryotic counterpart, RNA Pol (polymerase) II. A novel atomic model of SshRNAP (Sulfolobus shibatae RNAP) in complex with dsDNA (double-stranded DNA) constitutes a new piece of information helping the understanding of the mechanisms for DNA ...

Global Transcription Regulators of Eukaryotes

et al., 1975). The nucleosome core is composed of an octamer of four highly folded proteins, H2A, H2B, H3, and H4 (two of each protein), and of 147 base pairs of independent of the DNA sequence. Networks of ordered 69126 Heidelberg water molecules are found at the histone–subunit inter-Germany faces and at histone–DNA contact sites. They might thus Institute for Molecular Biology and Biophysics...

FOXO Transcription Factors as Regulators